Development of a user guide to support administration of the MRC Prion Disease Rating Scale in research and clinical settings for prion diseases
The final User Guide was designed to accompany the MRC Scale and assist with rater decisions related to which response option most accurately describes a patient's health status. Conclusions: The User Guide is expected to be a valuable complement to the MRC Scale, which is poised to rise in use and prominence as global clinical research efforts accelerate to address the significant unmet need of PrD patients.
Authors
- Nurit Omer (ORCID: https://orcid.org/0009-0002-1282-8051)
- Inga Zerr (ORCID: https://orcid.org/0000-0002-6722-2463)
- Aaron Yarlas (ORCID: https://orcid.org/0000-0003-4600-259X)
- Steven Collins (ORCID: https://orcid.org/0000-0002-5245-6611)
- Anne Smith (ORCID: https://orcid.org/0000-0001-8190-3006)
- Robert S. Pulido
- Brian S. Appleby (ORCID: https://orcid.org/0000-0003-2275-3292)
- Simon Mead (ORCID: https://orcid.org/0000-0002-4326-1468)
- Chris Marshall (ORCID: https://orcid.org/0000-0003-1486-8997)
- Hannah Edge
- J.P. Brandel
Institutions
- Centre National de la Recherche Scientifique (FR)
- Inserm (FR)
- The University of Melbourne (AU)
- Florey Institute of Neuroscience and Mental Health (AU)
- University Hospitals of Cleveland (US)
- Tel Aviv Sourasky Medical Center (IL)
- Ionis Pharmaceuticals (United States) (US)
- University Medical Center (US)
- Sorbonne Université (FR)
- Assistance Publique – Hôpitaux de Paris (FR)
- Health Economics and Outcomes Research (United Kingdom) (GB)
- MRC Prion Unit (GB)
- Clarivate (United States) (US)
- Institut du Cerveau (FR)
- University College London (GB)
- Case Western Reserve University (US)
Publication Details
- Journal
- Prion
- Published
- 2025-09-30
- DOI
- https://doi.org/10.1080/19336896.2025.2565204
- Primary Topic
- Prion Diseases and Protein Misfolding
- Type
- article
- Field-Weighted Citation Impact
- 0.00