UCHL1 enhances <i>TSC1</i> transcription by stabilizing FOXO1 through deubiquitination in knee osteoarthritis.
experiments demonstrated that UCHL1 alleviated cartilage damage in KOA rats by inhibiting ferroptosis and ECM degradation through the FOXO1/TSC1 axis. These findings demonstrate the pivotal role of UCHL1 in regulating ferroptosis and maintaining ECM homeostasis, offering novel insights into the molecular mechanisms driving KOA progression.
Authors
- Jiawei Lu (ORCID: https://orcid.org/0000-0003-0026-6434)
- Tao Jiang (ORCID: https://orcid.org/0000-0002-4487-299X)
- Yu Wang
- Zhongyu Xia
- Zikang Xie
- Bingqing Guo
- Chonghao Gu
Institutions
- Hangzhou Hospital of Traditional Chinese Medicine (CN)
Publication Details
- Journal
- PubMed
- Published
- 2026-05-01
- DOI
- https://doi.org/10.14670/hh-18-995
- Primary Topic
- NF-κB Signaling Pathways
- Type
- article
- Field-Weighted Citation Impact
- 0.00