The stress-responsive cytokine GDF-15 and sarcopenia: A systematic review and meta-analysis on aging muscle decline
Sarcopenic individuals had higher circulating GDF-15. Together with the inverse correlation between GDF-15 and muscle mass observed, these findings show a small-to-moderate association between elevated GDF-15 and sarcopenic phenotypes in older adults. However, the limited number of studies and high heterogeneity for the sarcopenia comparison warrant cautious interpretation and underscore the need for larger, longitudinal investigations.
Authors
- Mario Virgilio Papa (ORCID: https://orcid.org/0000-0002-1579-2202)
- Giuseppe Sergi (ORCID: https://orcid.org/0000-0001-9757-856X)
- Raffaele Pagliuca (ORCID: https://orcid.org/0000-0002-8033-737X)
- Chiara Ceolin (ORCID: https://orcid.org/0000-0001-5064-1672)
- Marina De Rui (ORCID: https://orcid.org/0000-0003-4966-1312)
- Francesco Boschele
Institutions
- University of Padua (IT)
- Ospedale Sant'Anna (IT)
Publication Details
- Journal
- Mechanisms of Ageing and Development
- Published
- 2025-09-26
- DOI
- https://doi.org/10.1016/j.mad.2025.112117
- Citations
- 2
- Primary Topic
- GDF15 and Related Biomarkers
- Type
- article
- Field-Weighted Citation Impact
- 3.34