The scent of stimulation: Anterior commissure mediates olfactory phenomena induced by DBS of the ventral capsule/ventral striatum
Obsessive–compulsive disorder (OCD) affects 1.3% of the general population, with 10–20% of patients remaining refractory to standard treatment and therefore possible candidates for surgical intervention [1, 2]. In such refractory cases, deep brain stimulation (DBS) targeting the ventral capsule/ventral striatum (VC/VS) has shown long-term improvement in 66% of the implanted patients [3]. Stimulation of the VC/VS region often produces transient side effects during initial DBS programming with variable prognostic implications [4].
Authors
- Wayne K. Goodman (ORCID: https://orcid.org/0000-0001-6717-082X)
- Kasra Mansourian
- Garrett P. Banks (ORCID: https://orcid.org/0000-0001-6292-977X)
- Danika Paulo (ORCID: https://orcid.org/0000-0002-2292-1164)
- Kalman A. Katlowitz
- Tommy Liu (ORCID: https://orcid.org/0000-0003-4800-8418)
- Sarah R. Heilbronner (ORCID: https://orcid.org/0000-0003-0893-5364)
- Nisha Giridharan (ORCID: https://orcid.org/0000-0002-0142-1013)
- Katherine E. Kabotyanski (ORCID: https://orcid.org/0000-0001-9003-1588)
- Nicole R. Provenza (ORCID: https://orcid.org/0000-0002-6952-5417)
- Sameer A. Sheth (ORCID: https://orcid.org/0000-0001-8770-8965)
- Raja Jani (ORCID: https://orcid.org/0000-0002-5358-4068)
- Mohammed Hasen
- Ajay Gandhi
- Zain Naqvi (ORCID: https://orcid.org/0009-0000-3895-8386)
- S Sehgal
- Shragvi Balaji (ORCID: https://orcid.org/0009-0001-8956-080X)
- Jane H. Bentley
- Corey St. Romain
Institutions
- University of Louisville (US)
- Baylor College of Medicine (US)
- University of Louisville Hospital (US)
- University of Louisville Physicians (US)
- Imam Abdulrahman Bin Faisal University (SA)
Publication Details
- Journal
- Brain stimulation
- Published
- 2025-09-27
- DOI
- https://doi.org/10.1016/j.brs.2025.09.017
- Primary Topic
- Olfactory and Sensory Function Studies
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- National Institutes of Health