Multiomics combined with machine learning defines unique molecular subtypes of cholangiocarcinoma and identifies TNK1 as a therapeutic target
Integrated multiomic characterization provides translational insights by defining unique molecular subtypes associated both with therapeutic response and overall clinical outcomes. This approach identified TNK1 as a previously unrecognized therapeutic target in a defined subset of CCA tumors.
Authors
- Dong‐Gi Mun (ORCID: https://orcid.org/0000-0003-3588-3440)
- Gregory James Gores (ORCID: https://orcid.org/0000-0003-3151-009X)
- Sumera I. Ilyas (ORCID: https://orcid.org/0000-0002-2709-3003)
- Chantal E. McCabe (ORCID: https://orcid.org/0000-0003-2786-5496)
- Joshua L. Andersen (ORCID: https://orcid.org/0000-0003-2071-744X)
- Rohit Budhraja (ORCID: https://orcid.org/0000-0002-4209-2180)
- Mitesh J. Borad (ORCID: https://orcid.org/0000-0003-2700-2658)
- Roberto Alva‐Ruiz (ORCID: https://orcid.org/0000-0002-9796-8098)
- Jack W. Sample (ORCID: https://orcid.org/0000-0002-1837-0291)
- Akhilesh Pandey (ORCID: https://orcid.org/0000-0001-9943-6127)
- Ellen L. Larson (ORCID: https://orcid.org/0000-0002-9420-5941)
- Danielle M. Carlson (ORCID: https://orcid.org/0000-0003-1823-6380)
- Lewis R. Roberts (ORCID: https://orcid.org/0000-0001-7885-8574)
- Martin Golkowski (ORCID: https://orcid.org/0000-0002-0996-1655)
- Kathryn Woods‐Townsend (ORCID: https://orcid.org/0000-0003-3376-6988)
- Rondell Patrell Graham (ORCID: https://orcid.org/0000-0002-8686-4867)
- Ryan Watkins (ORCID: https://orcid.org/0000-0002-7061-3238)
- Rory L. Smoot (ORCID: https://orcid.org/0000-0001-8543-661X)
- Erik Jessen (ORCID: https://orcid.org/0000-0001-9851-6897)
- Jennifer L. Tomlinson (ORCID: https://orcid.org/0000-0002-0909-3165)
- Amro M. Abdelrahman (ORCID: https://orcid.org/0000-0001-9865-0551)
- Richard K. Kandasamy (ORCID: https://orcid.org/0000-0002-0894-1222)
- Caitlin B. Conboy (ORCID: https://orcid.org/0000-0001-8280-056X)
- Chen Wang (ORCID: https://orcid.org/0000-0003-2638-3081)
- Marshall S. Baker
- Lindsey A. Gregory
- Enis H. Ozmert
Institutions
- Mayo Clinic (US)
- Manipal Academy of Higher Education (IN)
- University of Utah (US)
- Huntsman Cancer Institute (US)
- WinnMed (US)
- Utah Department of Health (US)
- Mayo Clinic in Arizona (US)
- Mayo Clinic in Florida (US)
Publication Details
- Journal
- Hepatology
- Published
- 2025-09-29
- DOI
- https://doi.org/10.1097/hep.0000000000001535
- Citations
- 2
- Primary Topic
- Cholangiocarcinoma and Gallbladder Cancer Studies
- Type
- article
- Field-Weighted Citation Impact
- 4.01