Ocular Solute Movement Direction and Intracranial Clearance via Vitreous Gadolinium-based Contrast Agent MR Imaging: Potential as a Novel Biomarker for Glymphatic Dysfunction
The anteroposterior distribution of GBCA in the vitreous is a novel, non-invasive imaging biomarker associated with impaired brain clearance function. This "contrast shift index" may reflect systemic glymphatic dysregulation common to both the eye and brain, offering a new avenue for assessing neurodegenerative risk.
Authors
- Tadao Yoshida (ORCID: https://orcid.org/0000-0001-9993-0766)
- Shinji Naganawa
- Mariko Kawamura (ORCID: https://orcid.org/0000-0001-9211-4934)
- Michihiko Sone (ORCID: https://orcid.org/0000-0001-7380-610X)
- Toshiaki Taoka (ORCID: https://orcid.org/0000-0001-9227-0240)
- Rintaro Ito (ORCID: https://orcid.org/0000-0002-7971-043X)
Institutions
- Nagoya University (JP)
Publication Details
- Journal
- Magnetic Resonance in Medical Sciences
- Published
- 2025-09-25
- DOI
- https://doi.org/10.2463/mrms.mp.2025-0127
- Citations
- 2
- Primary Topic
- Cerebrospinal fluid and hydrocephalus
- Type
- article
- Field-Weighted Citation Impact
- 1.82