Impact of silencing automated penicillin cross-reactivity alerts on perioperative antibiotic prescribing and surgical site infection rates
We evaluated the impact of silencing penicillin cross-reactivity alerts on perioperative antibiotic prescribing and surgical site infections (SSIs) in 6 hospitals using an interrupted time series analysis. Silencing the alerts minimally increased cefazolin prescribing among penicillin allergy labeled patients (sensitivity analysis only; <i>P</i> = 0.03) and had no influence on SSIs (<i>P</i> = 0.32).
Authors
- Alice Bewley
- Helen Newland
- Andrew Atkinson (ORCID: https://orcid.org/0000-0001-5834-8315)
- Kimberly G. Blumenthal (ORCID: https://orcid.org/0000-0003-4773-9817)
- Jonas Marschall (ORCID: https://orcid.org/0000-0002-0052-3210)
- Michael J. Durkin (ORCID: https://orcid.org/0000-0003-4652-7089)
- Joshua Nordman (ORCID: https://orcid.org/0000-0001-9644-501X)
Institutions
- BJC HealthCare (US)
- Harvard University (US)
- University of Arizona (US)
- University of Phoenix (US)
- Washington University in St. Louis (US)
- Massachusetts General Hospital (US)
Publication Details
- Journal
- Infection Control and Hospital Epidemiology
- Published
- 2025-09-29
- DOI
- https://doi.org/10.1017/ice.2025.10311
- Citations
- 1
- Primary Topic
- Clinical Laboratory Practices and Quality Control
- Type
- article
- Field-Weighted Citation Impact
- 1.16