Multiple gene knockouts in newts reveal novel functions of <i>5′ Hox</i> genes in limb development along the anterior–posterior and proximal–distal axes
These findings indicate that Hox9 and Hox10 redundantly regulate stylopod formation in the hindlimbs. Furthermore, Hox9/Hox10 and Hox11 contribute to the development of the anterior and posterior regions of the zeugopod/autopod in the hindlimbs, respectively. These novel roles of 5' Hox genes identified in newts suggest the functional diversification of 5' Hox genes in tetrapod limb development.
Authors
- Takashi Takeuchi (ORCID: https://orcid.org/0000-0001-9308-1302)
- Gembu Abe (ORCID: https://orcid.org/0000-0002-9905-8506)
- Kayoko Urakawa
- Toshinori Hayashi (ORCID: https://orcid.org/0000-0003-3676-5710)
- Haruka Matsubara (ORCID: https://orcid.org/0000-0002-3974-6630)
- Yutaka Ito (ORCID: https://orcid.org/0000-0001-8939-7101)
- Kenichi Suzuki (ORCID: https://orcid.org/0000-0002-4502-831X)
- Shuji Shigenobu (ORCID: https://orcid.org/0000-0003-4640-2323)
- Masatoshi Matsunami (ORCID: https://orcid.org/0000-0003-4109-2493)
Institutions
- Hiroshima University (JP)
- National Institute for Basic Biology (JP)
- University of the Ryukyus (JP)
- Tottori University (JP)
Publication Details
- Journal
- Developmental Dynamics
- Published
- 2025-09-29
- DOI
- https://doi.org/10.1002/dvdy.70080
- Primary Topic
- Developmental Biology and Gene Regulation
- Type
- article
- Field-Weighted Citation Impact
- 0.00