Phytoconstituents of Indian mustard honey impart antidepressant activity in reserpine-induced depressed condition through activation of TrkB/CREB/BDNF pathway in hippocampus
MH demonstrated antioxidant, neuroprotective and antidepressant activities in <i>in vitro</i> and <i>in vivo</i> models, suggesting therapeutic potential. However, further studies on additional pathways, including β-catenin/Wnt, MAPK/ERK, along with pharmacokinetics, are essential before recommending MH as an antidepressant agent.
Authors
- Surendra Kumar Saini (ORCID: https://orcid.org/0000-0001-5869-8040)
- P.K. Biswas (ORCID: https://orcid.org/0000-0002-7001-1798)
- Viney Kumar (ORCID: https://orcid.org/0000-0003-3677-3489)
- Kaushik Ghosh (ORCID: https://orcid.org/0000-0002-3792-2848)
- Partha Roy (ORCID: https://orcid.org/0000-0003-1943-3079)
- Samrat Chauhan (ORCID: https://orcid.org/0000-0003-4120-6534)
- Tiyasa Pathak
- Prabhat Kumar
- Rajat Saini
- Saakshi Saini
- Thakur Gurjeet Singh
Institutions
- Indian Institute of Technology Roorkee (IN)
- Ministry of Agriculture & Farmers Welfare (IN)
- Chitkara University (IN)
Publication Details
- Journal
- Nutritional Neuroscience
- Published
- 2025-09-29
- DOI
- https://doi.org/10.1080/1028415x.2025.2554363
- Primary Topic
- Bee Products Chemical Analysis
- Type
- article
- Field-Weighted Citation Impact
- 0.00