Comparative cardiovascular risk of sulfonylureas with low‐ and high‐affinities for cardiac mitochondrial adenosine triphosphate‐sensitive potassium channels versus dipeptidyl peptidase‐4 inhibitors in patients with type 2 diabetes: A cohort study
Initiating low-affinity mitoK<sub>ATP</sub>-channel sulfonylureas demonstrated cardiovascular safety comparable to DPP-4i, whereas high-affinity sulfonylureas were linked to increased cardiovascular risk and all-cause mortality. These findings suggest low-affinity sulfonylureas are a safer alternative to high-affinity agents and as safe as DPP-4i. They may be appropriate for individuals with diabetes when newer therapies are inaccessible or unnecessary.
Authors
- Jun‐Ting Liou (ORCID: https://orcid.org/0000-0003-4107-0788)
- Tzu‐Han Lin
- Tzu‐Chieh Lin (ORCID: https://orcid.org/0000-0002-6542-2023)
- Ta‐Chuan Hung (ORCID: https://orcid.org/0000-0003-1845-242X)
- Mengting Wang (ORCID: https://orcid.org/0000-0003-2153-6632)
- Mei‐Hsiu Chen (ORCID: https://orcid.org/0000-0002-6007-5560)
- Yu‐Cheng Chen (ORCID: https://orcid.org/0000-0003-1696-4667)
- Chia-Yu Li
- Liang-Yu Lin
Institutions
- National Yang Ming Chiao Tung University (TW)
- China Medical University (TW)
- Ming Chuan University (TW)
- Taipei Veterans General Hospital (TW)
- Far Eastern Memorial Hospital (TW)
- China Medical University Hospital (TW)
Publication Details
- Journal
- Diabetes Obesity and Metabolism
- Published
- 2025-09-29
- DOI
- https://doi.org/10.1111/dom.70157
- Primary Topic
- Cardiovascular Function and Risk Factors
- Type
- article
- Field-Weighted Citation Impact
- 0.00