Maternal body composition and the placental-fetal unit under maternal high-fat feeding partially improve by metformin treatment or lifestyle interventions during pregnancy in a mouse model
Although all tested interventions had beneficial effects on the mother and the placental-fetal unit, NI seems to be most promising. Our findings highlight that preventive strategies for women with obesity should aim for pre-counseling advisory service. In particular, NI and RUN protected from endothelial stress response and metformin was vasculo-protective, offering strategies to preserve the physiological placental-fetal unit and materno-fetal nutrient supply.
Authors
- Peter Zentis (ORCID: https://orcid.org/0000-0002-6999-132X)
- Sarah Appel (ORCID: https://orcid.org/0000-0003-0315-6513)
- Eva Nüsken (ORCID: https://orcid.org/0000-0002-0674-804X)
- Angela Köninger (ORCID: https://orcid.org/0000-0003-2721-7210)
- Maria Wohlfarth
- Tobias Kretschmer (ORCID: https://orcid.org/0000-0002-7830-7825)
- A.W. Thiele
- Jörg Dötsch (ORCID: https://orcid.org/0000-0003-1529-7647)
- Marion Handwerk
- Ruth Janoschek (ORCID: https://orcid.org/0000-0002-1332-9353)
- Alexandra Gellhaus (ORCID: https://orcid.org/0000-0001-9506-4581)
- Inga Bae‐Gartz (ORCID: https://orcid.org/0000-0002-4061-503X)
- Merlin D. Kammerer
- Miguel Angel Alejandre Alcazar (ORCID: https://orcid.org/0000-0002-3176-0411)
- Dirk Gründemann (ORCID: https://orcid.org/0000-0003-0914-0299)
- Eva Hucklenbruch‐Rother (ORCID: https://orcid.org/0000-0002-8876-3533)
- Kai‐Dietrich Nüsken (ORCID: https://orcid.org/0000-0001-5749-7183)
- Eva‐Maria Turnwald
- Simone Kalis
- Ciara Kallage
- Lena Neweling
Institutions
- University of Cologne (DE)
- University Hospital Cologne (DE)
- University of Duisburg-Essen (DE)
Publication Details
- Journal
- Placenta
- Published
- 2025-09-25
- DOI
- https://doi.org/10.1016/j.placenta.2025.09.016
- Citations
- 2
- Primary Topic
- Birth, Development, and Health
- Type
- article
- Field-Weighted Citation Impact
- 6.99