Plasma p‐tau217, NfL, GFAP diagnostic performance and biomarker profiles in Alzheimer's disease, frontotemporal dementia, and psychiatric disorders, in a prospective unselected neuropsychiatry memory clinic
Plasma p-tau217 was significantly elevated in AD compared to other disorders. P-tau217 distinguished AD from bvFTD with high accuracy. P-tau217 distinguished AD from PPDs with high accuracy. NfL/p-tau217 ratio and GFAP added limited diagnostic value compared to p-tau217 and NfL. Findings support blood biomarkers in younger, real-world clinical cohorts.
Authors
- Charles Benjamin Malpas (ORCID: https://orcid.org/0000-0003-0534-3718)
- Kaj Blennow (ORCID: https://orcid.org/0000-0002-1890-4193)
- Courtney Lewis (ORCID: https://orcid.org/0000-0001-6041-5118)
- Q.-X. Li
- Steven Collins (ORCID: https://orcid.org/0000-0002-5245-6611)
- Colin L. Masters (ORCID: https://orcid.org/0000-0003-3072-7940)
- Christa Dang (ORCID: https://orcid.org/0000-0003-0905-282X)
- Matthew Kang (ORCID: https://orcid.org/0000-0001-9375-3762)
- Dhamidhu Eratne (ORCID: https://orcid.org/0000-0002-3226-7645)
- Dennis Velakoulis (ORCID: https://orcid.org/0000-0002-8842-8479)
- Oneil G. Bhalala (ORCID: https://orcid.org/0000-0002-4412-7009)
- Henrik Zetterberg (ORCID: https://orcid.org/0000-0003-3930-4354)
- Samantha M. Loi (ORCID: https://orcid.org/0000-0002-4953-4500)
- Alexander Santillo (ORCID: https://orcid.org/0000-0001-9717-0820)
Institutions
- University of Science and Technology of China (CN)
- The Royal Melbourne Hospital (AU)
- University of Wisconsin–Madison (US)
- Federation University (AU)
- The University of Melbourne (AU)
- Lund University (SE)
- Walter and Eliza Hall Institute of Medical Research (AU)
- Florey Institute of Neuroscience and Mental Health (AU)
- Sahlgrenska University Hospital (SE)
- National Ageing Research Institute (AU)
- Profu (Sweden) (SE)
- Australian Psychological Society (AU)
- Victoria University (AU)
- University of Gothenburg (SE)
Publication Details
- Journal
- Alzheimer s & Dementia
- Published
- 2025-09-30
- DOI
- https://doi.org/10.1002/alz.70717
- Citations
- 3
- Primary Topic
- Dementia and Cognitive Impairment Research
- Type
- article
- Field-Weighted Citation Impact
- 4.41