Sotatercept for Pulmonary Arterial Hypertension within the First Year after Diagnosis
Among adults with pulmonary arterial hypertension who had received the diagnosis less than 1 year earlier, the addition of sotatercept to background therapy resulted in a lower risk of clinical worsening than placebo. (Funded by Merck Sharp and Dohme, a subsidiary of Merck [Rahway, NJ]; HYPERION ClinicalTrials.gov number, NCT04811092.).
Authors
- Ioana R. Preston (ORCID: https://orcid.org/0000-0002-1378-7362)
- Michela Brambatti (ORCID: https://orcid.org/0000-0001-9605-8220)
- Marius M. Hoeper (ORCID: https://orcid.org/0000-0001-9086-2293)
- Grzegorz Kopeć (ORCID: https://orcid.org/0000-0001-9921-2801)
- Harald S. Mackenzie
- Aaron B. Waxman (ORCID: https://orcid.org/0000-0001-7797-0361)
- J. Simon R. Gibbs (ORCID: https://orcid.org/0000-0001-6147-9252)
- Wei Fu (ORCID: https://orcid.org/0000-0001-5248-7891)
- Mardi Gomberg‐Maitland (ORCID: https://orcid.org/0000-0003-0482-4560)
- Joerg Koglin (ORCID: https://orcid.org/0000-0002-0073-1845)
- David B. Badesch
- Vallerie V. McLaughlin (ORCID: https://orcid.org/0000-0002-8907-1651)
- Barry Miller
- Samuel S. Kim (ORCID: https://orcid.org/0000-0002-9612-5312)
- Marc Humbert (ORCID: https://orcid.org/0000-0003-0703-2892)
- Hossein Ardeschir Ghofrani (ORCID: https://orcid.org/0000-0002-2029-4419)
- Rogério Souza (ORCID: https://orcid.org/0000-0003-2789-9143)
- Yaru Shi (ORCID: https://orcid.org/0000-0001-8063-3825)
- Gisela Meyer (ORCID: https://orcid.org/0000-0002-9425-7872)
- Mahesh J. Patel
- Karen M. Olsson
- Alexandra G. Cornell
Institutions
- Jagiellonian University (PL)
- Merck & Co., Inc., Rahway, NJ, USA (United States) (US)
- Inserm (FR)
- George Washington University (US)
- Université Paris-Saclay (FR)
- University of Michigan (US)
- Medizinische Hochschule Hannover (DE)
- Irmandade da Santa Casa de Misericórdia de São Paulo (BR)
- Assistance Publique – Hôpitaux de Paris (FR)
- Lung Institute (US)
- John Paul II Hospital (PL)
- Hypertension pulmonaire : physiopathologie et innovation thérapeutique (FR)
- Lahey Medical Center (US)
- German Center for Lung Research (DE)
- Universities of Giessen and Marburg Lung Center (DE)
- Hospital das Clínicas da Faculdade de Medicina da Universidade de São Paulo (BR)
- Woman's Hospital (US)
- Imperial College London (GB)
- University of Colorado Anschutz Medical Campus (US)
Publication Details
- Journal
- New England Journal of Medicine
- Published
- 2025-09-30
- DOI
- https://doi.org/10.1056/nejmoa2508170
- Citations
- 14
- Primary Topic
- Pulmonary Hypertension Research and Treatments
- Type
- article
- Field-Weighted Citation Impact
- 21.26