Differential Peripheral NLRP3 Inflammasome Expression in Patients With Parkinson’s Disease and Patients With Multiple System Atrophy
Our findings challenge the prevailing hypothesis that NLRP3 inflammasome activation directly contributes to PD pathogenesis. Instead, the observed increase in ASC and caspase-1 expression suggests the potential involvement of alternative inflammasome pathways during disease progression.
Authors
- Hữu Đạt Nguyễn (ORCID: https://orcid.org/0000-0003-2491-5566)
- Hyeo‐Il Ma (ORCID: https://orcid.org/0000-0001-6733-9779)
- In Hee Kwak (ORCID: https://orcid.org/0000-0002-5968-7199)
- Han‐Joon Kim (ORCID: https://orcid.org/0000-0001-8219-9663)
- Jeffrey Lee (ORCID: https://orcid.org/0000-0002-0607-9261)
- Suk Jun Song
- Young‐Eun Kim (ORCID: https://orcid.org/0000-0003-0694-6844)
- T. Nguyen Thanh (ORCID: https://orcid.org/0009-0007-3430-9443)
- HK Choi
Institutions
- Hallym University (KR)
- Seoul National University Hospital (KR)
- Hallym University Sacred Heart Hospital (KR)
- Hallym University Chuncheon Sacred Heart Hospital (KR)
- Hallym University Medical Center (KR)
Publication Details
- Journal
- Journal of Movement Disorders
- Published
- 2025-09-30
- DOI
- https://doi.org/10.14802/jmd.25124
- Primary Topic
- Parkinson's Disease Mechanisms and Treatments
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- National Research Foundation
- Korea Health Industry Development Institute
- National Research Foundation of Korea
- Ministry of Science and ICT, South Korea