Distant metastases of melanoma exhibit varying extent of intrapatient proteogenomic heterogeneity
Comprehensive proteogenomic profiling of post-mortem melanoma metastases, collected primarily before the immunotherapy era. Description of 1177 protein sequence variants predicted by RNA-Seq and validated via mass spectrometry-based proteomics. Empirical evidence of prominent intrapatient heterogeneity, driven by heterogeneous protein expression related to cell cycle- and mitochondrial processes, immune system and extracellular matrix organization.
Authors
- Zsolt Horváth (ORCID: https://orcid.org/0000-0002-5376-7737)
- Henriett Oskolás (ORCID: https://orcid.org/0000-0001-7217-6433)
- Henrik Lindberg
- Aniel Sánchez (ORCID: https://orcid.org/0000-0002-0278-8802)
- Bo Baldetorp
- Beáta Szeitz (ORCID: https://orcid.org/0000-0001-6414-0537)
- Jeovanis Gil (ORCID: https://orcid.org/0000-0003-3601-3893)
- Indira Plá (ORCID: https://orcid.org/0000-0002-0839-7829)
- Lazaro Hiram Betancourt (ORCID: https://orcid.org/0000-0001-8207-7041)
- Zoltán G. Páhi (ORCID: https://orcid.org/0000-0002-3428-553X)
- Réka Mohácsi
- Johan Malm (ORCID: https://orcid.org/0000-0002-9365-7313)
- Imre Boros (ORCID: https://orcid.org/0000-0001-8504-9687)
- Magdolna Herold (ORCID: https://orcid.org/0000-0002-1036-6343)
- Victor Guryev (ORCID: https://orcid.org/0000-0002-5810-6022)
- Zoltán Herold (ORCID: https://orcid.org/0000-0001-5990-4889)
- Tibor Pankotai (ORCID: https://orcid.org/0000-0001-9810-5465)
- Elisabet Wieslander
- Magdalena Kuras (ORCID: https://orcid.org/0000-0002-9479-423X)
- David Fenyö (ORCID: https://orcid.org/0000-0001-5049-3825)
- József Tı́már (ORCID: https://orcid.org/0000-0001-9183-0859)
- Roger Appelqvist (ORCID: https://orcid.org/0000-0001-7450-7216)
- Yanick Hagemeijer (ORCID: https://orcid.org/0000-0001-6036-3741)
- Krzysztof Pawłowski (ORCID: https://orcid.org/0000-0002-5367-0935)
- Jimmy Rodriguez Murillo
- Attila Marcell Szász (ORCID: https://orcid.org/0000-0003-2739-4196)
- Zsuzsanna Újfaludi (ORCID: https://orcid.org/0000-0003-4738-0963)
- Viktória Doma
- Péter Horvatovich (ORCID: https://orcid.org/0000-0003-2218-1140)
- Melinda Rezeli (ORCID: https://orcid.org/0000-0003-4373-5616)
- Jéssica de Siqueira Guedes (ORCID: https://orcid.org/0000-0002-8061-1623)
- István Balázs Németh (ORCID: https://orcid.org/0000-0003-0161-4277)
- Yutaka Sugihara (ORCID: https://orcid.org/0000-0002-4406-3017)
- György Marko‐Varga
- Lajos V. Kemény (ORCID: https://orcid.org/0000-0002-8233-1844)
Institutions
- Semmelweis University (HU)
- Universidade Federal do Rio de Janeiro (BR)
- Howard Hughes Medical Institute (US)
- University of Groningen (NL)
- Lund University (SE)
- University of Szeged (HU)
- Instituto Federal do Rio de Janeiro (BR)
- HUN-REN Szegedi Biológiai Kutatóközpont (HU)
- Karolinska Institutet (SE)
- Skåne University Hospital (SE)
- New York University (US)
- The University of Texas Southwestern Medical Center (US)
Publication Details
- Journal
- Clinical and Translational Medicine
- Published
- 2025-09-28
- DOI
- https://doi.org/10.1002/ctm2.70477
- Citations
- 1
- Primary Topic
- Immunotherapy and Immune Responses
- Type
- article
- Field-Weighted Citation Impact
- 0.80