Lipid emulsion in blood increases extraction of amitriptyline in liposome augmented peritoneal dialysis in rats chronically dosed with amitriptyline: could nanoparticles mitigate the limitations to dialysis in intoxication?
These are the first data to our knowledge showing experimental support for the approach of simultaneously decreasing volume of distribution with an intravascular nanoparticle in conjunction with a drug binding particle in dialysate. Further work in this area is warranted.
Authors
- Jessie Bee Kim Koh (ORCID: https://orcid.org/0000-0003-2186-4871)
- Martyn Harvey (ORCID: https://orcid.org/0000-0002-8808-1823)
- Debra Chalmers
- Grant Cave (ORCID: https://orcid.org/0000-0001-9992-8252)
- Matthew Quance
Institutions
- Waikato Regional Council (NZ)
- Hawke's Bay Hospital (NZ)
- Hawke's Bay Regional Council (NZ)
Publication Details
- Journal
- Intensive Care Medicine Experimental
- Published
- 2025-09-30
- DOI
- https://doi.org/10.1186/s40635-025-00812-1
- Primary Topic
- Pharmacological Effects and Toxicity Studies
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- AgResearch