Presurgical Succinate MetAstatic Risk Tool (P-SMART) in Paragangliomas
Though limited by sample size and retrospective design, our findings suggest that succinate is a minimally invasive biomarker that could enhance preoperative metastatic risk stratification, especially when integrated into a multiparametric score such as P-SMART. Larger prospective studies are needed to validate its role, but P-SMART could optimize clinical decision-making, refine patient selection for whole-body imaging, reduce unnecessary radiation exposure, and inform surveillance strategies.
Authors
- Lorenzo Zanatta
- Tonino Ercolino
- Fabio Staderini (ORCID: https://orcid.org/0000-0002-2438-2563)
- Clotilde Sparano (ORCID: https://orcid.org/0000-0002-3766-4682)
- Mario Maggi (ORCID: https://orcid.org/0000-0003-3267-4221)
- Francesca Amore
- Letizia Canu (ORCID: https://orcid.org/0000-0003-4995-8108)
- Alice Santi (ORCID: https://orcid.org/0000-0003-3400-5507)
- Elena Rapizzi (ORCID: https://orcid.org/0000-0002-3826-2714)
- Niccolò Galeotti
Institutions
- El.En. Group (Italy) (IT)
- Azienda Ospedaliero-Universitaria Careggi (IT)
- Istituto Nazionale di Documentazione Innovazione e Ricerca Educativa (IT)
- University of Florence (IT)
- Union des Industries Ferroviaires Européennes (BE)
Publication Details
- Journal
- Endocrine Pathology
- Published
- 2025-09-30
- DOI
- https://doi.org/10.1007/s12022-025-09878-9
- Citations
- 2
- Primary Topic
- Adrenal and Paraganglionic Tumors
- Type
- article
- Field-Weighted Citation Impact
- 4.01
Funders
- Università degli Studi di Firenze
- Associazione Italiana per la Ricerca sul Cancro