Silencing the fibronectin gene <i>(FN1</i> ) improves NaCl‐induced cardiac fibrosis via ferritinophagy‐mediated ferroptosis in a nuclear receptor coactivator 4 (NCOA4)‐dependent manner
Overall, our finding identified that silencing Fn1 possessed beneficial effects against NaCl-induced cardiac fibrosis through downregulating the ferroptosis of NRCFs, which was attributed to the inhibition of NOCA4-mediated ferritinophagy.
Authors
- Yawei Dai
- Kun Zhao (ORCID: https://orcid.org/0000-0002-0602-6258)
- Xiaoliang Yang (ORCID: https://orcid.org/0000-0003-0136-1935)
- Yu Zhou (ORCID: https://orcid.org/0000-0003-1844-2045)
- Yong Li
- Peng Li (ORCID: https://orcid.org/0000-0002-6260-8383)
- Yukang Mao
- Yang Chuanxi
Institutions
- Zhongshan Hospital (CN)
- Wuxi People's Hospital (CN)
- Yangpu Hospital of Tongji University (CN)
- Nanjing Medical University (CN)
Publication Details
- Journal
- British Journal of Pharmacology
- Published
- 2025-09-29
- DOI
- https://doi.org/10.1111/bph.70205
- Citations
- 2
- Primary Topic
- Extracellular vesicles in disease
- Type
- article
- Field-Weighted Citation Impact
- 1.61