Perturbation of Circulating Inflammatory Proteins Mediates the Relationship Between Cholecystectomy and Nonalcoholic Fatty Liver Disease: A Multivariate and Mediation Mendelian Randomization Study
Cholecystectomy is an independent risk factor for NAFLD. Circulating TNFRSF9 as a key inflammatory mediator explains ~10.76% of the increased NAFLD risk following cholecystectomy. These findings highlight TNFRSF9 as a potential biomarker and therapeutic target for preventing postcholecystectomy NAFLD, although further validation is required.
Authors
- Jilin Chen
- Cong Chen (ORCID: https://orcid.org/0009-0003-8852-7543)
- Jinming Chen (ORCID: https://orcid.org/0000-0002-3425-5939)
Institutions
- Zhuhai People's Hospital (CN)
Publication Details
- Journal
- Health Science Reports
- Published
- 2025-09-29
- DOI
- https://doi.org/10.1002/hsr2.71303
- Primary Topic
- Liver Disease Diagnosis and Treatment
- Type
- article
- Field-Weighted Citation Impact
- 0.00