Catecholaminergic nucleus integrity and Alzheimer's pathology, symptoms, and progression
In symptomatic AD, LC integrity reflects cortical AD pathology, measured by pTau217. LC integrity predicts cognitive function in AD, independent of cortical atrophy. LC and SN integrity independently relate to attentional performance. Symptoms of anxiety, depression, and apathy are associated with lower LC integrity. LC and SN relate to cognitive decline rate and left LC predicts atrophy rate.
Authors
- Magdalena Kolanko (ORCID: https://orcid.org/0000-0002-0058-5884)
- Peter Lally (ORCID: https://orcid.org/0000-0003-0075-0103)
- Paresh Malhotra (ORCID: https://orcid.org/0000-0002-1897-0780)
- Ramin Nilforooshan (ORCID: https://orcid.org/0000-0001-9801-183X)
- Gregory Scott (ORCID: https://orcid.org/0000-0001-8063-5871)
- Thomas D. Parker (ORCID: https://orcid.org/0000-0001-7679-4220)
- Cecilia Olivares
- David Sharp (ORCID: https://orcid.org/0000-0003-4995-2240)
- Christina Triantafyllou
- Karl Zimmerman (ORCID: https://orcid.org/0000-0003-1239-3414)
- Michael David (ORCID: https://orcid.org/0000-0002-8724-2840)
- Jason Brandt (ORCID: https://orcid.org/0000-0001-7381-6244)
- Karen Hoang (ORCID: https://orcid.org/0000-0002-2846-6852)
Institutions
- Kensington College of Business (GB)
- UK Dementia Research Institute (GB)
- University College London (GB)
- Imperial College London (GB)
- Surrey and Borders Partnership NHS Foundation Trust (GB)
Publication Details
- Journal
- Alzheimer s & Dementia
- Published
- 2025-09-29
- DOI
- https://doi.org/10.1002/alz.70749
- Primary Topic
- Alzheimer's disease research and treatments
- Type
- article
- Field-Weighted Citation Impact
- 0.00