Neonatal Choledocholithiasis: A Rare but Challenging Surgical Scenario

Choledocholithiasis is a rare diagnosis in neonates, and there are no standard management guidelines for this population. Additionally, endoscopic retrograde cholangiopancreatography (ERCP) is often not an option due to the small size of the common bile duct and non-availability of appropriately sized neonatal endoscopes. We present the cases of two neonates with choledocholithiasis. Both patients underwent open cholecystectomy with common bile duct exploration. The biliary stones were not removable, and therefore both underwent a Roux-en-Y hepaticojejunostomy. Both neonates have done well postoperatively. While hyperbilirubinemia is common in neonates, choledocholithiasis is challenging to diagnose. Diagnosis requires a broad differential and the use of abdominal ultrasound. While ERCP is the gold standard in adults, it is difficult to perform in neonates. Therefore, other treatment modalities involving laparoscopic and open surgery may be necessary. There is a need for improved management guidelines and endoscopic treatment options for neonates with choledocholithiasis.

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Publication Details

Journal
Cureus
Published
2025-09-29
DOI
https://doi.org/10.7759/cureus.93518
Primary Topic
Gallbladder and Bile Duct Disorders
Type
article
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article

Neonatal Choledocholithiasis: A Rare but Challenging Surgical Scenario

Emily Greenwald, Tamara N. Fitzgerald, Ruby Lopez-Flores, Debra L. Sudan et al.
Cureus
Gallbladder and Bile Duct Disorders
article

Neonatal Choledocholithiasis: A Rare but Challenging Surgical Scenario

Emily Greenwald, Tamara N. Fitzgerald, Ruby Lopez-Flores, Debra L. Sudan, Fengming Chen, Steven W. Thornton, Eden Singh, Deepak Vikraman Sushama
article en

Abstract

Choledocholithiasis is a rare diagnosis in neonates, and there are no standard management guidelines for this population. Additionally, endoscopic retrograde cholangiopancreatography (ERCP) is often not an option due to the small size of the common bile duct and non-availability of appropriately sized neonatal endoscopes. We present the cases of two neonates with choledocholithiasis. Both patients underwent open cholecystectomy with common bile duct exploration. The biliary stones were not removable, and therefore both underwent a Roux-en-Y hepaticojejunostomy. Both neonates have done well postoperatively. While hyperbilirubinemia is common in neonates, choledocholithiasis is challenging to diagnose. Diagnosis requires a broad differential and the use of abdominal ultrasound. While ERCP is the gold standard in adults, it is difficult to perform in neonates. Therefore, other treatment modalities involving laparoscopic and open surgery may be necessary. There is a need for improved management guidelines and endoscopic treatment options for neonates with choledocholithiasis.

CureusVol. 17(9)
Duke University (US), Duke Medical Center (US), Duke University Hospital (US)
Openalex Percentile: Top 61%
Gallbladder and Bile Duct Disorders
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Neonatal Choledocholithiasis: A Rare but Challenging Surgical Scenario — Emily Greenwald, Tamara N. Fitzgerald, et al. · Cureus (2025) | TGRS Research Map | TGRS