Single‐nucleus transcriptomic profiling reveals temporal dynamics of neuroinflammation and myelin repair after intracerebral haemorrhage
Establish intracerebral haemorrhage (ICH) mouse models at various time points (Days 1, 3, 7, 14, 28) and construct a high-quality single-nucleus RNA sequencing (snRNA-seq) atlas. Computational analyses suggest that macrophage recruitment in the early stage of ICH potentially involves migration inhibitory factor (MIF) signalling pathways. T cells may interact with myelin-forming oligodendrocytes during the resolution phase, potentially contributing to remyelination after ICH.
Authors
- Chuanyu Liu (ORCID: https://orcid.org/0000-0003-2258-0897)
- Longqi Liu (ORCID: https://orcid.org/0000-0002-5828-5542)
- Ruoqi Ding
- Nannan Cheng (ORCID: https://orcid.org/0000-0003-2608-388X)
- Zhan Chen (ORCID: https://orcid.org/0009-0009-6016-5476)
- Rong Xiang (ORCID: https://orcid.org/0000-0002-3243-2057)
- Mengke Zhao (ORCID: https://orcid.org/0000-0003-0142-3470)
- Qinglin Wang (ORCID: https://orcid.org/0000-0002-9202-5656)
- Shaoshuai Wang (ORCID: https://orcid.org/0000-0003-0315-7866)
- Tao Jin (ORCID: https://orcid.org/0000-0003-2912-3517)
- Jiaxin Li (ORCID: https://orcid.org/0000-0001-7228-2877)
- Jian Wang (ORCID: https://orcid.org/0000-0003-2291-640X)
- Mingyue Wang (ORCID: https://orcid.org/0000-0001-9370-3896)
- Qidi Xue
- Junmin Wang (ORCID: https://orcid.org/0000-0003-1823-5388)
- Xuemei Chen (ORCID: https://orcid.org/0000-0002-4435-5159)
- Qinfeng Peng
Institutions
- BGI Group (China) (CN)
- Shanxi Medical University (CN)
- Zhengzhou University (CN)
- University of Chinese Academy of Sciences (CN)
- BGI Research (CN)
Publication Details
- Journal
- Clinical and Translational Medicine
- Published
- 2025-09-28
- DOI
- https://doi.org/10.1002/ctm2.70486
- Primary Topic
- Immune cells in cancer
- Type
- article
- Field-Weighted Citation Impact
- 0.00