Immunohistochemical Characterisation of Innate Immune Cellular Responses in Cutaneous Leishmaniasis Caused by <scp> <i>Leishmania donovani</i> </scp>

Our findings suggest that early innate immune responses, particularly M1 macrophage polarisation, keratinocyte activation, and Langerhans cell involvement, contribute to treatment success in Sri Lankan cutaneous leishmaniasis caused by L. donovani , highlighting localised mechanisms of protective immunity.

Authors

P.A.B.H. Amarathunga
Nilakshi Samaranayake (ORCID: https://orcid.org/0000-0001-5654-1189)
Nadira D. Karunaweera (ORCID: https://orcid.org/0000-0003-3985-1817)
Hasna Riyal (ORCID: https://orcid.org/0000-0002-7395-9103)
Deepani Munidasa

Institutions

Rajarata University of Sri Lanka (LK)
University of Colombo (LK)

Publication Details

Journal: Tropical Medicine & International Health
Published: 2025-09-28
DOI: https://doi.org/10.1111/tmi.70040
Primary Topic: Research on Leishmaniasis Studies
Type: article
Field-Weighted Citation Impact: 0.00

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article

Immunohistochemical Characterisation of Innate Immune Cellular Responses in Cutaneous Leishmaniasis Caused by Leishmania donovani

P.A.B.H. Amarathunga, Nilakshi Samaranayake, Nadira D. Karunaweera, Hasna Riyal et al.

Sep 28, 2025

Tropical Medicine & International Health

Research on Leishmaniasis Studies

article

Immunohistochemical Characterisation of Innate Immune Cellular Responses in Cutaneous Leishmaniasis Caused by Leishmania donovani

P.A.B.H. Amarathunga, Nilakshi Samaranayake, Nadira D. Karunaweera, Hasna Riyal, Deepani Munidasa

September 28, 2025article en

Abstract

Our findings suggest that early innate immune responses, particularly M1 macrophage polarisation, keratinocyte activation, and Langerhans cell involvement, contribute to treatment success in Sri Lankan cutaneous leishmaniasis caused by L. donovani , highlighting localised mechanisms of protective immunity.

Tropical Medicine & International HealthVol. 30(12)

Rajarata University of Sri Lanka (LK), University of Colombo (LK)

Openalex Percentile: Top 64%

Research on Leishmaniasis Studies

DOI Source OpenAlex

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Immunohistochemical Characterisation of Innate Immune Cellular Responses in Cutaneous Leishmaniasis Caused by <scp> <i>Leishmania donovani</i> </scp> — P.A.B.H. Amarathunga, Nilakshi Samaranayake, et al. · Tropical Medicine & International Health (2025) | TGRS Research Map | TGRS