Distinct Clinical and Cytokine Features of Moderate-Severe Persistent AR Phenotype by ARIA Classification: COCOA
These findings suggest that 4.4% of Korean children had a moderate-to-severe persistent AR phenotype, as defined by ARIA. Early sensitization to <i>Der p</i>, <i>Der f</i>, birch, and Japanese hop at age 3 and prenatal antibiotic use are risk factors. Furthermore, this phenotype may involve both T helper 2 and T helper 17-related immune responses, reflecting a potential shift toward more complex or mixed patterns of inflammation.
Authors
- Kangmo Ahn (ORCID: https://orcid.org/0000-0001-7751-9829)
- Da Kyeong Lee
- Youn Ho Shin
- Kun Baek Song (ORCID: https://orcid.org/0000-0001-6981-6292)
- Eun Young Baek
- Soo‐Jong Hong (ORCID: https://orcid.org/0000-0003-1409-2113)
- Eom Ji Choi (ORCID: https://orcid.org/0000-0002-1122-1592)
- Dong In Suh (ORCID: https://orcid.org/0000-0002-7817-8728)
- Hyo Won Lee (ORCID: https://orcid.org/0000-0003-0391-7140)
- Min Jee Park (ORCID: https://orcid.org/0000-0003-0891-1311)
- Jihyun Kim (ORCID: https://orcid.org/0000-0001-8493-2881)
- Kyung Won Kim (ORCID: https://orcid.org/0000-0003-4529-6135)
- Ji Soo Park (ORCID: https://orcid.org/0000-0002-0522-7736)
- So‐Yeon Lee (ORCID: https://orcid.org/0000-0002-2499-0702)
- Jisun Yoon (ORCID: https://orcid.org/0000-0002-4904-9118)
- Seung‐Hwa Lee (ORCID: https://orcid.org/0000-0001-9359-0318)
Institutions
- Ulsan College (KR)
- Seoul National University (KR)
- Yonsei University (KR)
- Soonchunhyang University (KR)
- Severance Hospital (KR)
- Samsung Medical Center (KR)
- University of Ulsan (KR)
- The Catholic University of Korea Yeouido St. Mary's Hospital (KR)
- Digital Science (United States) (US)
- National Medical Center (KR)
- Chung-Ang University Hospital (KR)
- Hallym University Sacred Heart Hospital (KR)
- CHA University Gangnam Medical Center (KR)
- Sungkyunkwan University (KR)
- Catholic University of Korea (KR)
Publication Details
- Journal
- Allergy Asthma and Immunology Research
- Published
- 2025-01-01
- DOI
- https://doi.org/10.4168/aair.2025.17.5.563
- Primary Topic
- Asthma and respiratory diseases
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Ministry of Environment
- Ministry of Education, India
- Korea National Institute of Health
- Korea Environmental Industry and Technology Institute