Serum small RNA profiling identifies prognostic biomarkers for sepsis mortality prediction

This study identifies circulating small RNAs as highly promising novel biomarkers for sepsis outcome prediction, substantially outperforming traditional clinical parameters. The exceptional diagnostic accuracy of combined tsRNA and miRNA signatures suggests significant potential for clinical translation to improve sepsis prognosis and patient stratification. These findings provide a foundation for developing molecular-based prognostic tools that could enhance sepsis management and guide therapeutic decision-making in critically ill patients.