Centella asiatica enhances diabetic wound healing by decreasing macrophage-driven inflammation via the AKT/MAPK/NF-κB pathway
This study demonstrates that <i>Centella asiatica</i> facilitates diabetic wound healing through anti-inflammatory mechanisms involving the AKT/MAPK/NF-κB pathway. These findings provide mechanistic support for the potential integration of <i>Centella asiatica</i> into DFU management.
Authors
- Zixiao Duan
- Shunli Rui (ORCID: https://orcid.org/0000-0002-1251-6747)
- Botao Tang
- Wenwen Zeng (ORCID: https://orcid.org/0000-0001-8544-3318)
- Chengjie Wu (ORCID: https://orcid.org/0000-0002-1203-5468)
- Qin Li (ORCID: https://orcid.org/0000-0002-6700-4167)
- Huan Chen (ORCID: https://orcid.org/0000-0002-5089-2719)
- Qingqing Chen (ORCID: https://orcid.org/0009-0002-3708-0158)
- Bin Liu (ORCID: https://orcid.org/0009-0001-1286-9753)
- Fugang Xiao (ORCID: https://orcid.org/0009-0001-0496-1955)
Institutions
- The Affiliated Yongchuan Hospital of Chongqing Medical University (CN)
- Chongqing Emergency Medical Center (CN)
- Hanzhong Central Hospital (CN)
- Chongqing Medical University (CN)
Publication Details
- Journal
- Frontiers in Pharmacology
- Published
- 2025-09-29
- DOI
- https://doi.org/10.3389/fphar.2025.1632573
- Citations
- 3
- Primary Topic
- Medicinal Plants and Neuroprotection
- Type
- article
- Field-Weighted Citation Impact
- 7.14