Analysis of GSDMD-N abnormality promoting neutrophil NETs mediated RA disease through NLRP3-dependent pathway
These data position the NLRP3 inflammasome as a pivotal upstream regulator of GSDMD-dependent NETosis in RA. Targeting this axis-via inhibition of NLRP3 or blockade of GSDMD pore formation-ameliorates inflammatory joint pathology in vivo and constrains NETosis in vitro. Collectively, our findings support the NLRP3-GSDMD pathway as a promising therapeutic avenue for RA.
Authors
- Li Bai (ORCID: https://orcid.org/0000-0002-7895-1776)
- Huiyang Liu (ORCID: https://orcid.org/0000-0003-1827-7684)
- Bingle Li
- Yongfu Wang (ORCID: https://orcid.org/0000-0003-3499-0586)
- Lingyan Zhu
- Yali Sang
Institutions
- Baotou Medical College (CN)
Publication Details
- Journal
- Frontiers in Immunology
- Published
- 2025-09-29
- DOI
- https://doi.org/10.3389/fimmu.2025.1652608
- Primary Topic
- Inflammasome and immune disorders
- Type
- article
- Field-Weighted Citation Impact
- 0.00