Skin aging and immunosenescence
The skin covers the entire surface of the body and therefore is the largest organ in humans. The skin has various functions, primarily defence from infections and trauma. With aging, profound changes occur that compromise its key functions, leading to impaired barrier protection and immune responses. This is in part due to the increased low-grade systemic inflammation known as inflammaging, driven by senescent cells, and release of pro-inflammatory cytokines, to which the skin also significantly contributes. As a consequence of inflammaging, the skin’s function is compromized. The cellular and molecular components involved are summarized in this review.
Authors
- Daniela Frasca (ORCID: https://orcid.org/0000-0002-9816-6679)
- Alessia Paganelli (ORCID: https://orcid.org/0000-0002-0916-7769)
- Nataša Štrbo (ORCID: https://orcid.org/0000-0003-2152-2433)
- Sujad Younis (ORCID: https://orcid.org/0009-0001-3866-6751)
Institutions
- University of Miami (US)
- Istituto Dermopatico dell'Immacolata (IT)
- Istituti di Ricovero e Cura a Carattere Scientifico (IT)
- Sylvester Comprehensive Cancer Center (US)
Publication Details
- Journal
- Exploration of Immunology
- Published
- 2025-09-29
- DOI
- https://doi.org/10.37349/ei.2025.1003218
- Primary Topic
- Skin Protection and Aging
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- National Institutes of Health
- National Institute on Aging
- National Institute of Diabetes and Digestive and Kidney Diseases