Low-intensity muscle contraction exercise reduces pain sensitivity by modulating peripheral pathology and spinal sensitization in end-stage knee osteoarthritis rats
Despite no significant changes in cartilage or subchondral bone degeneration, these findings suggest that low-intensity muscle contraction exercise alleviates pain sensitivity by modulating peripheral pathology and central sensitization. This study highlights the potential of therapeutic exercise as a strategy for OA pain management.
Authors
- Yuki Nishi (ORCID: https://orcid.org/0000-0003-1554-9998)
- Ayumi Takahashi
- Minoru Okita
- Junya Sakamoto (ORCID: https://orcid.org/0000-0001-5621-2756)
- Ryo Sasaki (ORCID: https://orcid.org/0000-0002-3943-2973)
- Yuichiro Honda
- Satoko Motokawa
Institutions
- Japan Society for the Promotion of Science (JP)
- Fukuoka Hospital (JP)
- Nagasaki University (JP)
Publication Details
- Journal
- Frontiers in Pain Research
- Published
- 2025-09-29
- DOI
- https://doi.org/10.3389/fpain.2025.1644177
- Primary Topic
- Osteoarthritis Treatment and Mechanisms
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Japan Society for the Promotion of Science