PD-L1 expression in cerebrospinal fluid for leptomeningeal metastasis from solid tumors: preliminary assessment of clinical implications
Our study establishes a robust methodology for detecting CSF PD-L1 expression using ThinPrep LBC with immunocytochemistry for LM patients. This approach suggests potential utility of CSF PD-L1 expression as a biomarker for guiding intrathecal immunotherapy for LM from solid tumors.
Authors
- Lishi Wang (ORCID: https://orcid.org/0000-0003-2991-0211)
- Panpan Tai
- Miao Liu (ORCID: https://orcid.org/0000-0002-7975-6702)
- Xiaohong Chen (ORCID: https://orcid.org/0000-0002-9797-8384)
- Min Liu (ORCID: https://orcid.org/0000-0002-5059-3743)
- Guozi Yang (ORCID: https://orcid.org/0000-0003-4139-0546)
- Wu Yu (ORCID: https://orcid.org/0000-0002-4031-144X)
- Yuancheng Zhang (ORCID: https://orcid.org/0000-0002-2414-8363)
- Yushan Huang
- Hanran Lei (ORCID: https://orcid.org/0009-0009-9813-515X)
- Zhenyu Pan (ORCID: https://orcid.org/0000-0002-1272-6402)
Institutions
- Guangzhou Medical University (CN)
- Huizhou University (CN)
Publication Details
- Journal
- Frontiers in Immunology
- Published
- 2025-09-29
- DOI
- https://doi.org/10.3389/fimmu.2025.1681280
- Primary Topic
- Brain Metastases and Treatment
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Guangzhou Medical University
- Basic and Applied Basic Research Foundation of Guangdong Province