Dietary and circulating butyrate are independently associated with kidney function in diabetes: a dual-cohort analysis
This dual-cohort study provides the first epidemiological evidence that higher levels of butyrate-whether from dietary intake or serum concentration-are independently associated with better renal function in adults with diabetes. These findings underscore the relevance of the gut-kidney axis in diabetic kidney disease and suggest that enhancing endogenous butyrate production through diet or microbiota-targeted strategies may offer a novel avenue for renoprotection.
Authors
- Qi Gao (ORCID: https://orcid.org/0000-0002-1965-7411)
- Sinan Ai
- Zhenjie Chen (ORCID: https://orcid.org/0000-0002-3033-8470)
- Zhen Wang (ORCID: https://orcid.org/0000-0003-4310-6692)
- Yaoxian Wang
- Aoshuang Li
- Leying Zhao
- Cong Zhao
Institutions
- Beijing University of Chinese Medicine (CN)
- Chinese Academy of Medical Sciences & Peking Union Medical College (CN)
- China-Japan Friendship Hospital (CN)
- PLA Rocket Force University of Engineering (CN)
- Dongzhimen Hospital Affiliated to Beijing University of Chinese Medicine (CN)
- Guang’anmen Hospital (CN)
- First Affiliated Hospital of Henan University (CN)
Publication Details
- Journal
- Frontiers in Nutrition
- Published
- 2025-09-29
- DOI
- https://doi.org/10.3389/fnut.2025.1671238
- Primary Topic
- Diet and metabolism studies
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- National Natural Science Foundation of China
- Beijing University of Chinese Medicine