LLM evaluation for thyroid nodule assessment: comparing ACR-TIRADS, C-TIRADS, and clinician-AI trust gap

While GPT-4o demonstrated superior diagnostic accuracy, clinicians most trusted DeepSeek-R1 combined with the C-TIRADS framework for generating practical, guideline-consistent recommendations. The findings highlight the critical need for alignment between AI-generated outputs and clinician expectations, and the importance of incorporating region-specific clinical guidelines (like C-TIRADS) for the effective real-world implementation of LLMs in thyroid nodule management decision support.

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Publication Details

Journal
Frontiers in Endocrinology
Published
2025-09-29
DOI
https://doi.org/10.3389/fendo.2025.1667809
Primary Topic
Thyroid Cancer Diagnosis and Treatment
Type
article
Field-Weighted Citation Impact
0.00
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article

LLM evaluation for thyroid nodule assessment: comparing ACR-TIRADS, C-TIRADS, and clinician-AI trust gap

Qingyan Ding, X Wang, Piaofei Chen, Chaoxue Zhang et al.
Frontiers in Endocrinology
Thyroid Cancer Diagnosis and Treatment
article

LLM evaluation for thyroid nodule assessment: comparing ACR-TIRADS, C-TIRADS, and clinician-AI trust gap

Qingyan Ding, X Wang, Piaofei Chen, Chaoxue Zhang, Yu Xi, Hui Liu, Wenjun Wang, Yu Zhang, Xi Dai, Yong Hu
article en

Abstract

While GPT-4o demonstrated superior diagnostic accuracy, clinicians most trusted DeepSeek-R1 combined with the C-TIRADS framework for generating practical, guideline-consistent recommendations. The findings highlight the critical need for alignment between AI-generated outputs and clinician expectations, and the importance of incorporating region-specific clinical guidelines (like C-TIRADS) for the effective real-world implementation of LLMs in thyroid nodule management decision support.

Frontiers in EndocrinologyVol. 16
Anhui Medical University (CN), Huangshan University (CN), First Affiliated Hospital of Anhui Medical University (CN)
Openalex Percentile: Top 64%
Thyroid Cancer Diagnosis and Treatment
DOIOpen Access PDFOpenAlex
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LLM evaluation for thyroid nodule assessment: comparing ACR-TIRADS, C-TIRADS, and clinician-AI trust gap — Qingyan Ding, X Wang, et al. · Frontiers in Endocrinology (2025) | TGRS Research Map | TGRS