Neutrophil extracellular traps: a novel contributor to vascular calcification in chronic kidney disease
Our results demonstrate that NET-related genes may contribute to CKD-associated vascular calcification in rodent models. Specifically, this work provides evidence for a potential mechanistic link between NET biology and vascular calcification in CKD, thereby offering insights into immune-vascular interactions and raising the possibility of exploring NET-targeted approaches to mitigate vascular damage.
Authors
- Yufeng Liang (ORCID: https://orcid.org/0009-0000-6072-6100)
- Yan Wang (ORCID: https://orcid.org/0000-0002-1210-0258)
- Wen‐Jun Li (ORCID: https://orcid.org/0000-0002-1233-736X)
- Wan Jianxin (ORCID: https://orcid.org/0000-0001-5343-3481)
Institutions
- Fujian Medical University (CN)
- Longyan University (CN)
- Mengchao Hepatobiliary Hospital (CN)
- First Affiliated Hospital of Fujian Medical University (CN)
Publication Details
- Journal
- Frontiers in Immunology
- Published
- 2025-09-29
- DOI
- https://doi.org/10.3389/fimmu.2025.1639166
- Primary Topic
- Neutrophil, Myeloperoxidase and Oxidative Mechanisms
- Type
- article
- Field-Weighted Citation Impact
- 0.00