Desensitization of TRPA1 by dimethyl itaconate attenuates acute and chronic pain in mice
Together, our findings demonstrate that DMI acts as a novel TRPA1 agonist for attenuating acute and chronic pain, possible through TRPA1 desensitization. Thus, DMI may be further developed as a potential therapeutic strategy for the treatment of acute and chronic pain.
Authors
- Xiaoguang Cui (ORCID: https://orcid.org/0009-0005-7689-5239)
- Guokun Zhou (ORCID: https://orcid.org/0000-0002-5755-507X)
- Sen Xu (ORCID: https://orcid.org/0000-0001-5098-371X)
- Peipei Kang (ORCID: https://orcid.org/0000-0001-8637-051X)
- Jiangtao Zhang (ORCID: https://orcid.org/0000-0002-5063-6854)
- Sijia Liu
- Ying Liu (ORCID: https://orcid.org/0000-0001-9385-992X)
- Junyi Ma
- Jiahui Lin (ORCID: https://orcid.org/0009-0003-5197-7567)
- Shiyu Sun (ORCID: https://orcid.org/0000-0002-4036-8921)
- Jin Zhao (ORCID: https://orcid.org/0009-0005-8905-8579)
Institutions
- Nantong University (CN)
Publication Details
- Journal
- Frontiers in Pharmacology
- Published
- 2025-09-29
- DOI
- https://doi.org/10.3389/fphar.2025.1671461
- Citations
- 1
- Primary Topic
- Ion Channels and Receptors
- Type
- article
- Field-Weighted Citation Impact
- 1.46
Funders
- National Natural Science Foundation of China