A flexible systems analysis pipeline for elucidating spatial relationships in the tumor microenvironment linked with cellular phenotypes and patient-level features
By integrating cell-segmented imaging data with interpretable modeling, our pipeline reveals key spatial determinants of tumor biology. These findings generate testable mechanistic hypotheses about intercellular interactions and support the development of spatially informed prognostic and therapeutic strategies.
Authors
- Gabriel F. Hanson (ORCID: https://orcid.org/0009-0003-0202-062X)
- Timothy N. J. Bullock (ORCID: https://orcid.org/0000-0001-6141-3261)
- Sepideh Dolatshahi (ORCID: https://orcid.org/0000-0003-0226-0933)
- Kate A. Goundry
- Remziye E. Wessel (ORCID: https://orcid.org/0000-0002-8596-4700)
- Michael G. Brown
Institutions
- Carter Center (US)
- Center for Neuroscience and Regenerative Medicine (US)
- University of Virginia (US)
Publication Details
- Journal
- Frontiers in Immunology
- Published
- 2025-09-29
- DOI
- https://doi.org/10.3389/fimmu.2025.1642527
- Citations
- 1
- Primary Topic
- Single-cell and spatial transcriptomics
- Type
- article
- Field-Weighted Citation Impact
- 0.81