Identification of novel genetic biomarkers for ChAdOx1 nCoV-19 mediated immunogenicity
Our study fills a critical gap by addressing the lack of research on genetic factors of ChAdOx1 nCoV-19 vaccine responses in Asian population, providing valuable insights into the genetic basis of DNA-based vaccine responses. The synergic host effect highlights the value of integrating genetic information with other host factors as a biomarker to predict individual vaccine responses. Our findings can contribute to personalized vaccination strategies and future vaccination policies.
Authors
- Wan‐Hsuan Chou (ORCID: https://orcid.org/0000-0002-7693-5959)
- Chun-Yu Wei
- Cheng-Lin Tsai
- Ching-Sheng Hung (ORCID: https://orcid.org/0000-0001-9442-4995)
- Min‐Rou Lin (ORCID: https://orcid.org/0000-0003-0247-1984)
- Lu-Chun Chen
- Ching-Hsuan Chao
- Wei-Tzu Luo
- Jude Chu-Chun Wang
- Wei‐Chih Liu
- Jafit Ting (ORCID: https://orcid.org/0000-0001-7918-8218)
- Hsiang-Yun Chi
- Hsin-Ni Liao
- Quynh Anh Nguyen (ORCID: https://orcid.org/0000-0002-9478-8307)
- Tsung-Hsun Wu
- Hui‐Wen Chang (ORCID: https://orcid.org/0000-0001-8877-1886)
- Che‐Mai Chang (ORCID: https://orcid.org/0000-0002-0353-9744)
- Shiao‐Ya Hong (ORCID: https://orcid.org/0000-0003-4302-1509)
- Wei‐Chiao Chang (ORCID: https://orcid.org/0000-0002-8573-5924)
- Yi-Chien Chou
- Szu-Ying Ho
- Shih-Hsin Hsiao
Institutions
- National Yang Ming Chiao Tung University (TW)
- Kaohsiung Medical University (TW)
- Taipei Medical University Hospital (TW)
- Wan Fang Hospital (TW)
- Taipei Medical University (TW)
Publication Details
- Journal
- Frontiers in Immunology
- Published
- 2025-09-29
- DOI
- https://doi.org/10.3389/fimmu.2025.1622122
- Primary Topic
- SARS-CoV-2 and COVID-19 Research
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- National Center for Global Health and Medicine
- Taipei Medical University
- National Science and Technology Council
- Taipei Medical University Hospital