The role of MTHFR polymorphism on hyperhomocysteinemia and folic acid and vitamin B metabolism

Non-communicable diseases (NCDs) remain a leading global health concern, with hyperhomocysteinemia recognized as a contributing metabolic disorder linked to cardiovascular disease, neurodegenerative conditions, and developmental anomalies. This presentation explores the pivotal role of methylenetetrahydrofolate reductase (MTHFR) polymorphisms—particularly C677T and A1298C variants—in disrupting homocysteine metabolism through impaired folate and vitamin B pathways.

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Publication Details

Journal
World Nutrition Journal
Published
2025-09-29
DOI
https://doi.org/10.25220/wnj.v09.s1.0010
Primary Topic
Folate and B Vitamins Research
Type
article
Field-Weighted Citation Impact
0.00
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article

The role of MTHFR polymorphism on hyperhomocysteinemia and folic acid and vitamin B metabolism

Rina Triana
World Nutrition Journal
Folate and B Vitamins Research
article

The role of MTHFR polymorphism on hyperhomocysteinemia and folic acid and vitamin B metabolism

Rina Triana
article en

Abstract

Non-communicable diseases (NCDs) remain a leading global health concern, with hyperhomocysteinemia recognized as a contributing metabolic disorder linked to cardiovascular disease, neurodegenerative conditions, and developmental anomalies. This presentation explores the pivotal role of methylenetetrahydrofolate reductase (MTHFR) polymorphisms—particularly C677T and A1298C variants—in disrupting homocysteine metabolism through impaired folate and vitamin B pathways.

World Nutrition JournalVol. 9(S1)
Riau University (ID)
Openalex Percentile: Top 61%
Folate and B Vitamins Research
DOIOpen Access PDFOpenAlex
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The role of MTHFR polymorphism on hyperhomocysteinemia and folic acid and vitamin B metabolism — Rina Triana · World Nutrition Journal (2025) | TGRS Research Map | TGRS