Coptidis rhizoma ameliorates type 2 diabetes mellitus-related metabolic dysfunction-associated steatohepatitis by downregulating the IL-17RA/NF-κB signaling pathway
<i>Coptidis rhizoma</i> ameliorates pathological phenotypes in T2DM-related MASH by inhibiting the IL-17RA/NF-κB signaling pathway, and its active metabolite epiberberine is involved in mediating these protective effects.
Authors
- Ning Yao (ORCID: https://orcid.org/0000-0001-9684-3018)
- Yunjuan Wu
- Yang Geng (ORCID: https://orcid.org/0009-0000-7153-4817)
- Ying Su (ORCID: https://orcid.org/0000-0001-8322-0655)
- Xuejun Wang (ORCID: https://orcid.org/0000-0001-9267-1343)
- Xiaomei Su (ORCID: https://orcid.org/0000-0002-0109-848X)
- Xiaoning Liu (ORCID: https://orcid.org/0000-0002-6794-8600)
- Limin Tian (ORCID: https://orcid.org/0000-0002-0630-0974)
- Yajie Chen (ORCID: https://orcid.org/0000-0001-6567-0396)
Institutions
- University of Electronic Science and Technology of China (CN)
- Gansu University of Traditional Chinese Medicine (CN)
- Lanzhou University (CN)
Publication Details
- Journal
- Frontiers in Pharmacology
- Published
- 2025-09-29
- DOI
- https://doi.org/10.3389/fphar.2025.1667937
- Primary Topic
- Liver Disease Diagnosis and Treatment
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- National Natural Science Foundation of China
- Natural Science Foundation of Gansu Province
- Gansu University of Chinese Medicine