Therapeutic potential of extracellular vesicles derived from Platycladus Orientalis leaf in treating anxiety, depression, and insomnia
<i>P. orientalis</i> leaf-derived EVs exert significant anxiolytic, antidepressant, and soporific effects through multimodal mechanisms involving neurotransmitter regulation and anti-inflammatory activity. Intranasal administration offers an effective strategy to bypass the blood -brain barrier, supporting the translational potential of plant-EVs as novel therapeutics for psychiatric disorders.
Authors
- Shaochang Jia
- Hongwei Liang (ORCID: https://orcid.org/0000-0002-8231-2790)
- Jia Meng (ORCID: https://orcid.org/0000-0003-3455-205X)
- Roger Fan
- Fan Wu (ORCID: https://orcid.org/0000-0003-0720-4674)
- Min Li (ORCID: https://orcid.org/0000-0002-0616-5215)
- Peiyu Liu (ORCID: https://orcid.org/0000-0002-2905-5473)
- Juanjuan He (ORCID: https://orcid.org/0000-0002-3565-5424)
- Gang He (ORCID: https://orcid.org/0000-0001-5801-0525)
- Bing Liu (ORCID: https://orcid.org/0009-0006-6780-4945)
- Yongping Lu
Institutions
- Army Medical University (CN)
- China Pharmaceutical University (CN)
- Nanjing Drum Tower Hospital (CN)
- Lushan Botanical Garden (CN)
Publication Details
- Journal
- Frontiers in Pharmacology
- Published
- 2025-09-29
- DOI
- https://doi.org/10.3389/fphar.2025.1693106
- Primary Topic
- Extracellular vesicles in disease
- Type
- article
- Field-Weighted Citation Impact
- 0.00