Arrhythmic events pertinent with antidepressants: a Bayesian disproportional analysis mining the FDA Adverse Event Reporting System database

Citalopram and escitalopram [classified as selective serotonin reuptake inhibitors (SSRIs)] exhibited the strongest correlations with arrhythmic occurrences. Quetiapine [classified as a second-generation antipsychotic (SGA)] demonstrated higher risk and worse prognosis on QT prolongation/TdP and ventricular arrhythmic events. Venlafaxine and duloxetine [classified as serotonin-norepinephrine reuptake inhibitors (SNRIs)] did not show any PV of any arrhythmia and had lower risks and a lower degree of adverse events compared with the rest. Certainly, more head-to-head related studies are merited.