Exploring the relationship and shared mechanisms of major depressive disorder and diabetic kidney disease: a comprehensive clinical and genetic analysis
Our findings demonstrate a genetic and immunological link between MDD and DKD. CD163 and KLRB1 may serve as potential biomarkers and therapeutic targets, offering new insights into the shared mechanisms and treatment strategies for comorbid MDD and DKD.
Authors
- H.-L. Liu
- Ya‐Jung Cheng (ORCID: https://orcid.org/0000-0001-9150-4690)
- Wen-xi Sun (ORCID: https://orcid.org/0000-0002-5855-5223)
- Chunhui Qu
- Xiangwen Wang (ORCID: https://orcid.org/0000-0002-4755-4639)
- Siyi Feng (ORCID: https://orcid.org/0000-0002-4707-8409)
- Tingting Wang (ORCID: https://orcid.org/0000-0002-8250-2594)
- Xiaohui Wu (ORCID: https://orcid.org/0000-0002-6119-8511)
- Ping Sun (ORCID: https://orcid.org/0000-0002-6572-307X)
Institutions
- Qingdao University (CN)
- Shanghai Mental Health Center (CN)
- Soochow University (CN)
- Qingdao Mental Health Center (CN)
- Suzhou Guangji Hospital (CN)
Publication Details
- Journal
- Frontiers in Psychiatry
- Published
- 2025-09-29
- DOI
- https://doi.org/10.3389/fpsyt.2025.1546733
- Primary Topic
- Tryptophan and brain disorders
- Type
- article
- Field-Weighted Citation Impact
- 0.00