Selenium: Could It Be the Game-Changer for Ocular Surface and Anterior Chamber in Graves' Disease?

Selenium supplementation is associated with better ocular surface parameters and different anterior segment architecture in euthyroid GD patients without ophthalmopathy. Clinical associations observed in these cases may be related to selenium's antioxidant and anti-inflammatory properties through glutathione peroxidase and thioredoxin reductase activity, suggesting selenium as a potentially beneficial therapeutic approach for ocular surface integrity in GD.