Spatially resolved endothelial signaling via nampt-itga5 drives immune evasion in stem-like gastric cancer
Our study delineates spatially defined cellular programs that contribute to immune escape in stem-like GC, highlighting a novel VISFATIN-integrin signaling axis as a potential biomarker and therapeutic target in immunotherapy-resistant tumors.
Authors
- Jae‐Ho Cheong (ORCID: https://orcid.org/0000-0002-1703-1781)
- Ji‐Yong Sung (ORCID: https://orcid.org/0000-0002-8397-1691)
- Eui Tae Kim (ORCID: https://orcid.org/0000-0002-1631-3197)
Institutions
- New Generation University College (ET)
- Seoul National University Bundang Hospital (KR)
- Yonsei University Health System (KR)
- Jeju National University Hospital (KR)
- Jeju National University (KR)
Publication Details
- Journal
- Cancer Immunology Immunotherapy
- Published
- 2025-09-29
- DOI
- https://doi.org/10.1007/s00262-025-04182-1
- Primary Topic
- Immune cells in cancer
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- National Research Foundation
- Korea Health Industry Development Institute
- National Research Foundation of Korea
- Ministry of Science and ICT, South Korea