Stress induces corticosterone-mediated CD8+ T cell exhaustion to promote non-small cell lung cancer
In brief, our study demonstrates that stress-corticosterone axis induces exhaustion of tumor-infiltrating CD8<sup>+</sup> T cells, contributing to accelerated progression of non-small cell lung cancer.
Authors
- Qiaoqi Zheng
- Qihao Weng (ORCID: https://orcid.org/0000-0002-2498-0934)
- Le Deng (ORCID: https://orcid.org/0000-0002-3476-2340)
- Peng Fei Fu (ORCID: https://orcid.org/0000-0002-7768-4004)
- Zaiquan Dong (ORCID: https://orcid.org/0000-0003-0226-239X)
- Jingcheng Dong (ORCID: https://orcid.org/0000-0002-5194-367X)
- Huijie Zhang (ORCID: https://orcid.org/0000-0003-0640-0315)
- Maimaititusun Yalikun (ORCID: https://orcid.org/0000-0002-6751-4431)
- Ji Zhuoga
Institutions
- Fudan University (CN)
- Huashan Hospital (CN)
Publication Details
- Journal
- Cancer Immunology Immunotherapy
- Published
- 2025-09-29
- DOI
- https://doi.org/10.1007/s00262-025-04179-w
- Citations
- 2
- Primary Topic
- Cancer, Stress, Anesthesia, and Immune Response
- Type
- article
- Field-Weighted Citation Impact
- 2.94