Genetic risk scores of psychiatric phenotypes are associated with depression risk in a prospective Dutch population-based cohort
The GRS and PRS for depression showed modest associations across multiple depression-related phenotypes in a population-based setting. The strength of associations generally increased with the severity of the phenotype. While effect sizes were generally larger for GRS compared to PRS, the difference was mostly not statistically significant.
Authors
- Annemarie I. Luik (ORCID: https://orcid.org/0000-0001-7517-197X)
- Amy Hofman (ORCID: https://orcid.org/0000-0003-0571-3774)
- M. Arfan Ikram
- André G. Uitterlinden (ORCID: https://orcid.org/0000-0002-7276-3387)
- Jeroen van Rooij (ORCID: https://orcid.org/0000-0001-9754-073X)
- Joyce B. J. van Meurs (ORCID: https://orcid.org/0000-0001-6245-2123)
- Annabel Vreeker (ORCID: https://orcid.org/0000-0003-2227-1234)
- Bahareh Sedaghati-khayat (ORCID: https://orcid.org/0000-0002-7665-8648)
Institutions
- Erasmus MC (NL)
- Erasmus University Rotterdam (NL)
Publication Details
- Journal
- Psychological Medicine
- Published
- 2025-01-01
- DOI
- https://doi.org/10.1017/s0033291725101943
- Primary Topic
- Genetic Associations and Epidemiology
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- European Commission
- ZonMw
- Erasmus Medisch Centrum