Complete loss of SLC30A8 in humans improves glucose metabolism and beta cell function
The corrected insulin response, disposition index and insulin sensitivity index in LoF heterozygotes and homozygotes indicated higher glucose-stimulated insulin secretion with preserved beta cell function that was independent of BMI. These data suggest that therapeutic inhibition of SLC30A8, up to and including complete knockout, may treat type 2 diabetes safely and effectively.
Authors
- Fazal Rehman Memon
- Makoto Asaumi
- Alan R. Shuldiner (ORCID: https://orcid.org/0000-0001-9921-4305)
- Ali Abbasi (ORCID: https://orcid.org/0000-0002-6452-4765)
- Lindsey B. Lamarche (ORCID: https://orcid.org/0000-0002-7200-3150)
- Christina Underwood
- Igor Splawski
- Danish Saleheen (ORCID: https://orcid.org/0000-0001-6193-020X)
- Allan Gurtan (ORCID: https://orcid.org/0000-0003-1701-7821)
- Muhammad Rehan Mian
- Allison B. Goldfine (ORCID: https://orcid.org/0000-0002-0345-1048)
- Riffat Sultana (ORCID: https://orcid.org/0000-0003-4775-8452)
- Muhammad Jahanzaib (ORCID: https://orcid.org/0000-0002-5101-8564)
- Anjum Jalal (ORCID: https://orcid.org/0000-0002-9448-811X)
- Ikuyo Kou
- Daniel P. Denning (ORCID: https://orcid.org/0000-0001-5667-3480)
- Juan L. Rodríguez-Flores (ORCID: https://orcid.org/0000-0002-0394-8062)
- Usman Abdulsalam
- Christopher Koch (ORCID: https://orcid.org/0000-0002-2754-3385)
- Jennifer Harrow (ORCID: https://orcid.org/0000-0003-0338-3070)
- John Dominy (ORCID: https://orcid.org/0000-0001-7137-0672)
- Kazuhisa Tsunoyama
- Mohammad Ishaq (ORCID: https://orcid.org/0000-0002-4087-9772)
- Richard Zessis
- Maleeha Khan (ORCID: https://orcid.org/0000-0001-5365-3353)
- Asif Rasheed
- Muhammad Hamid Saeed
- Shareef Khalid
- Shahid Abbas
- Matthew E. Clement
- Muhammad Bilal Liaqat
Institutions
- Novartis (Switzerland) (CH)
- Astellas Pharma (Japan) (JP)
- Punjab Institute of Cardiology (PK)
- Regeneron (United States) (US)
- Columbia University Irving Medical Center (US)
- Karachi Institute of Heart Diseases (PK)
- Novartis (China) (CN)
- AstraZeneca (South Korea) (KR)
- AstraZeneca (Singapore) (SG)
- Arrow International (United States) (US)
- University of Faisalabad (PK)
- Center for Non-Communicable Diseases (PK)
Publication Details
- Journal
- Diabetologia
- Published
- 2025-09-29
- DOI
- https://doi.org/10.1007/s00125-025-06530-3
- Citations
- 2
- Primary Topic
- Pancreatic function and diabetes
- Type
- article
- Field-Weighted Citation Impact
- 4.01