Vitamin A Deficiency Induces Congenital Vertebral Malformation via Retinoic Acid Signaling Mediated Sclerotome Dysplasia
We established a VAD-induced CVMs model. Non-Smad-dependent BMP pathway and RA signaling pathway may be related to the pathogenesis of CVMs. Our findings demonstrate that VAD may be one of the causes of CVMs, which is hypothesized to serve as a novel therapeutic target for the nonsurgical treatment of CVMs in the future.
Authors
- Junduo Zhao (ORCID: https://orcid.org/0000-0002-6102-9371)
- Bolun Qu
- Haoyu Cai (ORCID: https://orcid.org/0009-0008-2586-5111)
- Hongyi Zhou (ORCID: https://orcid.org/0009-0006-8391-671X)
- Xiaobin Hu (ORCID: https://orcid.org/0009-0006-0298-1940)
- Jianxiong Shen (ORCID: https://orcid.org/0000-0002-1606-4370)
- Yizhen Huang (ORCID: https://orcid.org/0009-0009-4130-0505)
- Heng Sun (ORCID: https://orcid.org/0009-0009-0624-0156)
- Xin Wan (ORCID: https://orcid.org/0000-0001-7377-1779)
- Yong Zhang (ORCID: https://orcid.org/0000-0002-2443-5143)
- Zhen Wang (ORCID: https://orcid.org/0000-0002-6997-8264)
- Yang Jiao (ORCID: https://orcid.org/0000-0001-9582-1650)
- Xuan Huang (ORCID: https://orcid.org/0000-0002-2677-7438)
- Haojie Chen (ORCID: https://orcid.org/0009-0005-4225-5460)
- Dahai Zhu (ORCID: https://orcid.org/0000-0002-1923-8858)
- Yuchang Zhou
- Jiafeng Dai (ORCID: https://orcid.org/0009-0001-5016-3639)
- Yingxi Chen
Institutions
- Chinese Academy of Medical Sciences & Peking Union Medical College (CN)
- Peking Union Medical College Hospital (CN)
- Jiangsu Province Hospital (CN)
- Nanjing Medical University (CN)
Publication Details
- Journal
- Neurospine
- Published
- 2025-09-29
- DOI
- https://doi.org/10.14245/ns.2550632.316
- Primary Topic
- Dermatological and Skeletal Disorders
- Type
- article
- Field-Weighted Citation Impact
- 0.00