Risk of depression with <scp>GLP</scp> ‐1 receptor agonists use in overweight or obese adults with type 2 diabetes: A new‐user, active‐comparator cohort study
GLP-1 RA initiation was associated with a statistically significant increase in depression risk compared to SGLT2i use (9% relative increase, 2.2% absolute risk difference over 1 year), particularly during the subacute period and in older adults. This observed association must be balanced against substantial mortality benefits. Enhanced monitoring and shared decision-making are warranted.
Authors
- Cheng‐Chen Chang (ORCID: https://orcid.org/0000-0002-9491-6866)
- Po‐Chung Ju (ORCID: https://orcid.org/0000-0002-6708-4339)
- Ming‐Hong Hsieh (ORCID: https://orcid.org/0000-0002-3128-8110)
- Yu Chang (ORCID: https://orcid.org/0000-0001-9954-921X)
Institutions
- Chung Shan Medical University Hospital (TW)
- Chung Shan Medical University (TW)
Publication Details
- Journal
- Diabetes Obesity and Metabolism
- Published
- 2025-09-29
- DOI
- https://doi.org/10.1111/dom.70175
- Citations
- 5
- Primary Topic
- Diabetes Treatment and Management
- Type
- article
- Field-Weighted Citation Impact
- 6.47