Proinflammatory polarization of adipose tissue macrophages in cows with subclinical ketosis constitutes a critical driver of adipose tissue remodeling and inflammation
Overall, the present study indicated an augmented macrophage presence within adipose tissue during subclinical ketosis, with a predominance of pro-inflammatory macrophages (M1 ATM). This observation suggested a vicious cycle wherein macrophage infiltration and pro-inflammatory polarization coincide with enhanced lipolysis and an amplified inflammatory cascade.
Authors
- Muhammad Usman (ORCID: https://orcid.org/0000-0002-9827-7838)
- Chuang Xu (ORCID: https://orcid.org/0000-0002-1163-6616)
- Bi-Chen Zhao
- Juan J. Loor (ORCID: https://orcid.org/0000-0003-1586-4365)
- Wanli Zhao
- Miao Li (ORCID: https://orcid.org/0000-0002-5501-2856)
- Renxu Chang (ORCID: https://orcid.org/0000-0002-9539-6671)
- Huijing Zhang (ORCID: https://orcid.org/0009-0004-3775-2510)
- Yue Yang (ORCID: https://orcid.org/0009-0006-5651-3202)
- Jingyi Wang (ORCID: https://orcid.org/0009-0006-2995-5494)
Institutions
- University of Illinois Urbana-Champaign (US)
- China Agricultural University (CN)
Publication Details
- Journal
- Journal of Animal Science and Biotechnology/Journal of animal science and biotechnology
- Published
- 2025-09-29
- DOI
- https://doi.org/10.1186/s40104-025-01252-3
- Citations
- 1
- Primary Topic
- Reproductive Physiology in Livestock
- Type
- article
- Field-Weighted Citation Impact
- 1.90
Funders
- National Natural Science Foundation of China
- China Agricultural University
- National Key Research and Development Program of China