Lyophilized horizontal platelet rich fibrin promotes the healing of infected burns/wounds by modulating macrophage polarization and fibroblast migration
The present study demonstrated that Ly-H-PRF promoted the healing of infected burn wounds by exerting an antibacterial effect, regulating macrophage polarization, and promoting skin fibroblast migration. Our results provide a pre-theoretical basis for the clinical application of Ly-H-PRF as an economical and convenient treatment for infection control and to promote tissue healing in infected burn wounds.
Authors
- Jihua Chai
- Nima Farshidfar (ORCID: https://orcid.org/0000-0003-2944-5305)
- Richard J. Miron (ORCID: https://orcid.org/0000-0003-3290-3418)
- Detian Miao
- Yulan Wang (ORCID: https://orcid.org/0000-0003-0502-6931)
- Xiaoxin Zhang (ORCID: https://orcid.org/0000-0001-7376-3736)
- Hualing Sun (ORCID: https://orcid.org/0000-0002-1886-4320)
- Shuo Xu (ORCID: https://orcid.org/0000-0003-2787-945X)
- Yi Bai
Institutions
- University of Bern (CH)
- Shandong University of Aeronautics (CN)
- Wuhan University (CN)
Publication Details
- Journal
- Frontiers in Bioengineering and Biotechnology
- Published
- 2025-09-29
- DOI
- https://doi.org/10.3389/fbioe.2025.1666265
- Citations
- 1
- Primary Topic
- Wound Healing and Treatments
- Type
- article
- Field-Weighted Citation Impact
- 1.03
Funders
- National Natural Science Foundation of China
- Wuhan University
- Osteology Foundation